Serotonin 1A receptor (5-HT1AR) function appears decreased in primary major
depressive disorder (MDD)
血清素1A受體(5-HT1AR)的功能在原發性重度憂鬱症(MDD)中出現下降
binding potential (BP)
結合電位(BP)
mesiotemporal cortex (MTC)
顳腦中葉皮質(MTC)
Mean 5-HT1AR BP was reduced 26% in MTC (p<0.005) and 43% in raphe (p<0.001)
in depressives versus controls.
與對照組相比,憂鬱症患者的平均5-HT1AR BP在MTC中降低了26%(p <0.005)
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Binding studies have shown that divalent cations increase the affinity of
5-hydroxytryptamine 1A (5-HT1A) receptors for ligands.
結合研究表明,二價陽離子可提高5-羥基色胺1A(5-HT1A)受體對配體的親和力。
This report demonstrates a functional role for Mg2+ in the operation of
the 5-HT1A receptor located on Purkinje cells.
該報告證明了Mg2+(鎂離子)在位於Purkinje細胞上的5-HT1A受體的運作中的功能性作用。
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Moreover, the in vivo studies indicate that Zn can modulate both presynaptic
and postsynaptic 5-HT1ARs
體內研究表明鋅可以調節突觸前和突觸後5-HT1ARs。
However, chronic zinc treatment induced increases in both 5-HT1AR protein levels
and density of 5-HT1A receptor binding sites in the Hp of rats.
然而,慢性鋅治療誘導大鼠Hp中5-HT1AR蛋白水平和5-HT1A受體結合位點密度增加。